Semen Yesylevskyy, visiting researcher from Institute of Physics of the National Academy of Sciences of Ukraine, will present his work in a talk titled “Approved drugs + membranes = surprises”.
Abstract: The vast majority of known drugs are designed to target protein or nucleic acids. The lipid membranes are almost never considered as the drug targets and are usually treated as just an unfortunate barrier for drug delivery inside the cell. As a result, most of the drugs are not even tested for interaction with the membranes. However, many drugs are amphiphilic and by their physical nature they are expected to incorporate into the membranes and stay there for a long time. In this talk I’ll demonstrate how common and widely used drugs could show surprising membranoropic properties that could have deep biomedical implications. It is also shown how one can target the lipid bilayer as a first-class druggable entity, which opens new perspectives for drug development.
The talk will take place in Lykeion at 11.00 as usual